Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy
Abstract Lateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical excitation.Abnormally high excitation produces epileptic seizures, which affect millions of people and need better treatments.HON population activity spikes from minute to minute, but the role Conductivity Gels of this in seizures is unknown.Here, we d